Question 1 of 78Cardiovascular Implants
The principal disadvantage of a mechanical prosthetic heart valve compared with a bioprosthesis is the:
ATendency to calcify rapidly
BInability to be used in the aortic position
CLimited durability of about ten years
DNeed for lifelong anticoagulation
Answer is hidden
Question 2 of 78Cardiovascular Implants
The material used for the leaflets of a modern bileaflet mechanical heart valve is:
AUHMWPE
BBovine pericardium
CPyrolytic carbon
DTitanium alloy
Answer is hidden
Question 3 of 78Cardiovascular Implants
Structural failure of a glutaraldehyde-fixed bioprosthetic valve occurs principally through:
ACorrosion of the sewing ring
BCreep of the pyrolytic carbon
CCalcification of the leaflets
DGalvanic attack
Answer is hidden
Question 4 of 78Cardiovascular Implants
Synthetic vascular grafts of less than 6 mm diameter fail mainly because of:
AExcessive porosity
BThrombosis and intimal hyperplasia at the anastomosis
CCalcification of the graft wall
DDissolution of the graft material
Answer is hidden
Question 5 of 78Cardiovascular Implants
Which material is used for a self-expanding carotid or peripheral artery stent?
APyrolytic carbon
B316L stainless steel
CNitinol
DCobalt-chromium
Answer is hidden
Question 6 of 78Cardiovascular Implants
The drug carried by a drug-eluting coronary stent acts to:
AInhibit smooth muscle proliferation and so reduce in-stent restenosis
BIncrease the radial strength of the stent
CDissolve the atherosclerotic plaque
DPrevent corrosion of the struts
Answer is hidden
Question 7 of 78Cardiovascular Implants
In the pacemaker code VVI, the third letter indicates that the pacemaker is:
AInhibited by a sensed intrinsic beat
BRate responsive
CImplanted in the ventricle
DTriggered by atrial activity
Answer is hidden
Question 8 of 78Cardiovascular Implants
A DDD pacemaker is chosen in preference to a VVI pacemaker mainly because it:
ACannot be affected by interference
BHas a smaller battery
CRequires no leads
DPreserves atrioventricular synchrony
Answer is hidden
Question 9 of 78Cardiovascular Implants
Pacemaker leads are frequently steroid-eluting at the electrode tip in order to:
APrevent infection of the pocket
BSuppress local inflammation and keep the stimulation threshold low
CIncrease the battery life directly
DImprove radiopacity
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Question 10 of 78Cardiovascular Implants
An inferior vena cava filter is indicated principally when a patient with venous thromboembolism:
ARequires a pacemaker
BCannot receive anticoagulation or has failed it
CHas an aortic aneurysm
DNeeds coronary bypass
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Question 11 of 78Cardiovascular Implants
The intra-aortic balloon pump inflates:
AAt the peak of systole
BContinuously throughout the cycle
CAt the onset of diastole, at the dicrotic notch
DAt the onset of systole
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Question 12 of 78Cardiovascular Implants
Helium is used to drive the intra-aortic balloon because it:
AHas a low density and can therefore be shuttled very rapidly
BIs radiopaque
CIs soluble in blood
DPrevents thrombosis
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Question 13 of 78Cardiovascular Implants
In a patient with a modern continuous-flow left ventricular assist device, the commonest site of infection is the:
AOutflow graft
BInflow cannula
CPump bearing
DPercutaneous driveline
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Question 14 of 78Orthopaedic Implants
The bearing surface material in the great majority of total hip and knee replacements is:
APMMA
BTitanium alloy
CUltra-high molecular weight polyethylene
DStainless steel
Answer is hidden
Question 15 of 78Orthopaedic Implants
PMMA bone cement fixes an implant to bone principally by:
AMechanical interlock with the cancellous bone
BChemical bonding to hydroxyapatite
CInducing bone ingrowth into the cement
DElectrostatic attraction
Answer is hidden
Question 16 of 78Orthopaedic Implants
For bone ingrowth into a cementless porous-coated implant to occur rather than fibrous tissue formation, micromotion must be kept below about:
A1 millimetre
B500 micrometres
C50 micrometres
D5 millimetres
Answer is hidden
Question 17 of 78Orthopaedic Implants
Large-head metal-on-metal hip bearings were largely withdrawn because of:
AExcessive volumetric wear of the metal
BAdverse tissue reaction to cobalt and chromium ions and nanoparticles
CAudible squeaking
DFrequent fracture of the head
Answer is hidden
Question 18 of 78Orthopaedic Implants
Increasing the diameter of the femoral head in a hip replacement with a polyethylene liner:
AHas no effect on wear
BEliminates the need for a liner
CReduces both instability and wear
DImproves stability but increases volumetric wear
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Question 19 of 78Orthopaedic Implants
The principal cause of late aseptic loosening of a hip replacement is:
AFatigue fracture of the stem
BFailure of the hydroxyapatite coating
CCorrosion of the acetabular shell
DOsteolysis provoked by polyethylene wear particles
Answer is hidden
Question 20 of 78Orthopaedic Implants
A ceramic-on-ceramic hip bearing offers the advantage of:
ALower cost than metal on polyethylene
BThe lowest wear rate of any bearing couple
CImmunity to fracture
DElimination of the need for fixation
Answer is hidden
Question 21 of 78Orthopaedic Implants
Compared with the hip, the knee is mechanically more demanding to replace because its motion involves:
APure rotation about a fixed centre
BOnly flexion in one plane
CCombined rolling, sliding and axial rotation with ligamentous stability
DNo load transmission
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Question 22 of 78Orthopaedic Implants
In a posterior-stabilised total knee replacement, the function of the posterior cruciate ligament is replaced by:
AAn all-polyethylene tibia
BA hinge
CA cam-and-post mechanism between the components
DA mobile bearing
Answer is hidden
Question 23 of 78Orthopaedic Implants
Increasing the conformity of a knee articulation lowers contact stress but has the drawback of:
APreventing flexion entirely
BTransmitting greater constraint forces to the fixation interface
CIncreasing polyethylene wear
DReducing the contact area
Answer is hidden
Question 24 of 78Orthopaedic Implants
Malalignment of the mechanical axis by a few degrees after total knee replacement is important because it causes:
AEdge loading with accelerated polyethylene wear and loosening
BCorrosion of the femoral component
CImmediate infection
DFracture of the cement mantle only
Answer is hidden
Question 25 of 78Orthopaedic Implants
Gentamicin is sometimes added to PMMA bone cement in order to:
AReduce the polymerisation exotherm
BProvide high local antibiotic concentration against infection
CMake the cement radiopaque
DIncrease the strength of the cement
Answer is hidden
Question 26 of 78Orthopaedic Implants
Titanium alloy is preferred for a cementless femoral stem rather than cobalt-chromium mainly because of its:
ALower cost
BLower elastic modulus and better osseointegration
CGreater hardness
DSuperior wear resistance
Answer is hidden
Question 27 of 78Urology Implants
The preferred material for a long-term indwelling urinary catheter is:
AStainless steel
BLatex
CPVC
DSilicone
Answer is hidden
Question 28 of 78Urology Implants
The balloon of a Foley catheter should be inflated with:
AAir
BContrast medium in all cases
CSterile water
DNormal saline
Answer is hidden
Question 29 of 78Urology Implants
A catheter of size 18 French has an external diameter of:
Answer is hidden
Question 30 of 78Urology Implants
The single most effective measure to reduce catheter-associated urinary tract infection is:
ARoutine weekly catheter change
BDaily bladder irrigation with antiseptic
CRemoving the catheter as soon as it is no longer needed
DProphylactic antibiotics for the duration of catheterisation
Answer is hidden
Question 31 of 78Urology Implants
The curled ends of a double-J ureteral stent serve to:
ADilate the ureter
BFilter crystals from the urine
CDeliver antibiotics
DPrevent migration up into the kidney or down into the bladder
Answer is hidden
Question 32 of 78Urology Implants
Encrustation of urinary catheters and stents is caused principally by:
AExcessive fluid intake
BDirect chemical attack on silicone by urea
CGalvanic corrosion
DUrease-producing bacteria raising the urine pH and precipitating struvite
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Question 33 of 78Urology Implants
The mineral that forms the bulk of catheter encrustation and infection stones is:
AUric acid
BCystine
CCalcium oxalate
DStruvite (magnesium ammonium phosphate)
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Question 34 of 78Urology Implants
A ureteral stent left in place and forgotten for a year is likely to:
AImprove renal function progressively
BBecome heavily encrusted and difficult or impossible to remove endoscopically
CDissolve harmlessly
DMigrate into the bloodstream
Answer is hidden
Question 35 of 78Urology Implants
Vesico-ureteric reflux may occur in a patient with a double-J stent because the stent:
ABlocks the urethra
BDissolves the ureteric muscle
CIncreases urine production
DHolds the vesico-ureteric junction open, defeating its flap-valve action
Answer is hidden
Question 36 of 78Urology Implants
Silver alloy coating of a urinary catheter is intended to:
AImprove radiopacity
BPrevent balloon rupture
CIncrease catheter stiffness
DReduce bacterial adhesion and colonisation
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Question 37 of 78Urology Implants
A Coude tip catheter is used particularly when:
AIntermittent self-catheterisation is planned
BContinuous irrigation is required
CThe patient has a suprapubic catheter
DAn enlarged prostate makes passage of a straight catheter difficult
Answer is hidden
Question 38 of 78Urology Implants
Polypropylene mid-urethral slings and pelvic meshes have become the subject of regulatory restriction mainly because of:
AErosion through tissue and chronic pain
BRapid biodegradation
CExcessive cost
DRadio-opacity artefacts
Answer is hidden
Question 39 of 78Urology Implants
An artificial urinary sphincter consists of:
AA metallic expandable stent
BAn inflatable silicone cuff, a pressure-regulating balloon and a pump
CA double-J stent with a valve
DA polypropylene mesh sling only
Answer is hidden
Question 40 of 78Plastic Surgery Implants
The commonest complication of breast implant surgery is:
AImplant rupture
BCapsular contracture
CBIA-ALCL
DInfection
Answer is hidden
Question 41 of 78Plastic Surgery Implants
A breast implant capsule that is firm, visibly distorted and painful is classified as Baker grade:
Answer is hidden
Question 42 of 78Plastic Surgery Implants
Cohesive silicone gel is preferred to older liquid gel because it:
AIs absorbed harmlessly by the body
BHolds its shape and does not migrate if the shell ruptures
CEliminates capsular contracture
DCan be injected through a needle
Answer is hidden
Question 43 of 78Plastic Surgery Implants
BIA-ALCL, a rare lymphoma arising in the implant capsule, has been associated particularly with:
ASubmuscular placement
BSaline-filled implants
CPeriareolar incisions
DMacrotextured implant shells
Answer is hidden
Question 44 of 78Plastic Surgery Implants
The great practical advantage of hyaluronic acid over permanent dermal fillers is that it:
ACannot cause swelling
BLasts for the patient's lifetime
CCan be dissolved with hyaluronidase if the result is poor or a vessel is occluded
DRequires no injection
Answer is hidden
Question 45 of 78Plastic Surgery Implants
The most serious complication of facial dermal filler injection is:
AThe Tyndall effect
BTemporary bruising
CIntravascular injection causing skin necrosis or blindness
DMild swelling for 48 hours
Answer is hidden
Question 46 of 78Plastic Surgery Implants
A bluish discoloration of the skin after hyaluronic acid filler placed too superficially is called:
ACapsular contracture
BThe Tyndall effect
CThe Vroman effect
DGranuloma formation
Answer is hidden
Question 47 of 78Plastic Surgery Implants
Integra, the classic dermal regeneration template, consists of:
ACultured keratinocyte sheets
BPolypropylene mesh
CBovine collagen and chondroitin-6-sulphate with a silicone outer layer
DPorcine xenograft skin
Answer is hidden
Question 48 of 78Plastic Surgery Implants
The principal limitation of cultured epidermal autograft in a massive burn is that it:
ALacks a dermis and takes about three weeks to produce
BCauses no scarring at all
CCannot be expanded from a biopsy
DIs rejected immunologically
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Question 49 of 78Plastic Surgery Implants
The gold standard for permanent coverage of a full-thickness burn remains:
ASplit-thickness autograft
BCadaveric allograft
CAmniotic membrane
DPorcine xenograft
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Question 50 of 78Plastic Surgery Implants
Resorbable plates and screws are preferred to titanium for craniofacial fixation in young children because they:
AAre radiopaque
BPromote osseointegration
CAre stronger than titanium
DDo not restrain skull growth and need no second operation for removal
Answer is hidden
Question 51 of 78Plastic Surgery Implants
A patient-specific cranioplasty implant is most commonly produced by:
AExtrusion of silicone gel
BCAD design from the patient's CT data followed by additive manufacturing
CCasting from a cadaveric skull
DHand carving in the operating theatre
Answer is hidden
Question 52 of 78Plastic Surgery Implants
In midface and mandibular fracture reconstruction, the reference used to guide reduction is the:
AOrbital rim only
BNasal septum
CPosition of the frontal sinus
DDental occlusion
Answer is hidden
Question 53 of 78Ophthalmic Implants
The commonest late complication after implantation of an intraocular lens is:
APosterior capsule opacification
BRetinal detachment
CEndophthalmitis
DCorneal decompensation
Answer is hidden
Question 54 of 78Ophthalmic Implants
A square posterior optic edge on a modern intraocular lens serves to:
AForm a mechanical barrier to lens epithelial cell migration
BFilter ultraviolet light
CIncrease the refractive power
DImprove folding of the lens
Answer is hidden
Question 55 of 78Ophthalmic Implants
Which intraocular lens material should be avoided in an eye that may later require silicone oil tamponade?
AHydrophilic acrylic
BPMMA
CHydrophobic acrylic
DSilicone
Answer is hidden
Question 56 of 78Ophthalmic Implants
The power of an intraocular lens is calculated principally from measurements of:
AIntraocular pressure and pupil size
BVisual acuity and colour vision
CAnterior chamber cell count
DAxial length and corneal curvature
Answer is hidden
Question 57 of 78Ophthalmic Implants
The original intraocular lens material, suggested by the observation that Perspex fragments were well tolerated in pilots' eyes, was:
ASilicone
BHydrogel
CPMMA
DPolypropylene
Answer is hidden
Question 58 of 78Ophthalmic Implants
Intrastromal corneal ring segments are implanted principally to treat:
AGlaucoma
BRetinal detachment
CKeratoconus
DCataract
Answer is hidden
Question 59 of 78Ophthalmic Implants
The principal engineering difficulty with a keratoprosthesis is:
ASterilising PMMA
BAchieving a durable seal between the synthetic optic and living tissue
CCalculating the correct refractive power
DManufacturing an optic of sufficient clarity
Answer is hidden
Question 60 of 78Ophthalmic Implants
An Ahmed glaucoma valve differs from a Baerveldt implant in that it:
AContains a pressure-sensitive membrane to limit early hypotony
BDrains into the vitreous cavity
CHas no tube
DIs made entirely of titanium
Answer is hidden
Question 61 of 78Ophthalmic Implants
The commonest cause of late failure of a glaucoma drainage device is:
ADissolution of the silicone
BCalcification of the optic
CFibrosis around the bleb or end plate restricting outflow
DCorrosion of the tube
Answer is hidden
Question 62 of 78Ophthalmic Implants
A porous hydroxyapatite orbital implant is preferred to a smooth PMMA sphere because it:
ABecomes vascularised, resisting migration and extrusion and allowing motility coupling
BIs transparent
CDissolves over time
DCan be adjusted in power
Answer is hidden
Question 63 of 78Ophthalmic Implants
A retinal prosthesis can restore some visual perception only when:
AThe optic nerve has been severed
BThe photoreceptors are lost but the inner retina and optic nerve remain functional
CThe lens has been removed
DThe cornea is opaque
Answer is hidden
Question 64 of 78Ophthalmic Implants
Current retinal prostheses provide vision that is best described as:
APhosphene-level perception allowing light localisation and some shape recognition
BComplete restoration of the visual field
CReading vision with fine detail
DNormal colour vision
Answer is hidden
Question 65 of 78Ophthalmic Implants
An ophthalmic viscosurgical device such as a hyaluronic acid preparation is used during cataract surgery to:
AStimulate capsule opacification
BDissolve the cataract
CProvide permanent refractive correction
DMaintain the anterior chamber and protect the corneal endothelium
Answer is hidden
Question 66 of 78Tissue Engineering
The three essential components of the tissue engineering triad are:
ACells, scaffold and signals
BPressure, flow and resistance
CMetal, ceramic and polymer
DAntigen, antibody and complement
Answer is hidden
Question 67 of 78Tissue Engineering
Induced pluripotent stem cells are attractive for tissue engineering because they:
AAre pluripotent yet can be derived from the patient's own cells
BRequire no culture
CCannot form tumours
DAre obtained from embryos
Answer is hidden
Question 68 of 78Tissue Engineering
An ideal tissue engineering scaffold should have a porosity of:
ALess than 10 %, to maximise strength
BAbout 50 %, with closed pores
CZero porosity
DMore than 90 %, with interconnected pores
Answer is hidden
Question 69 of 78Tissue Engineering
For bone tissue engineering, the pore size generally regarded as optimal for cell ingrowth and vascularisation is about:
A1 to 5 micrometres
B10 to 20 micrometres
C100 to 400 micrometres
D2 to 5 millimetres
Answer is hidden
Question 70 of 78Tissue Engineering
The degradation rate of a scaffold should ideally be:
AIrrelevant to the outcome
BAs slow as possible
CAs fast as possible
DMatched to the rate at which new tissue is formed
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Question 71 of 78Tissue Engineering
Which fabrication technique produces fibres of a diameter comparable to natural extracellular matrix fibrils?
AGas foaming
BSolvent casting and particulate leaching
CElectrospinning
DInjection moulding
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Question 72 of 78Tissue Engineering
In the basic procedure of tissue engineering, cells are released from a tissue biopsy by:
AGamma irradiation
BPlasma treatment
CFreeze-drying
DEnzymatic digestion with collagenase or trypsin
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Question 73 of 78Tissue Engineering
Dynamic seeding under perfusion is preferred to static seeding because it gives:
AA lower cell number
BSterility without processing
CFaster scaffold degradation
DMore uniform cell distribution throughout the scaffold
Answer is hidden
Question 74 of 78Tissue Engineering
The principal function of a perfusion bioreactor in tissue engineering is to:
ASterilise the scaffold
BReprogram the cells
CDeliver nutrients and oxygen to the interior of a thick construct and remove waste
DPrint the scaffold layer by layer
Answer is hidden
Question 75 of 78Tissue Engineering
The single greatest obstacle to engineering thick tissues and solid organs is:
AObtaining a suitable polymer
BDesigning the bioreactor vessel
CAchieving adequate vascularisation
DSterilising the construct
Answer is hidden
Question 76 of 78Tissue Engineering
Which tissue has been most successfully engineered and brought into clinical use?
Answer is hidden
Question 77 of 78Tissue Engineering
A decellularised donor organ is attractive as a scaffold because it retains:
ALiving donor cells
BThe donor's immune system
CIts original mechanical strength indefinitely
DThe native extracellular matrix architecture and vascular tree
Answer is hidden
Question 78 of 78Tissue Engineering
Mechanical loading is applied to a tissue-engineered tendon or cartilage construct in a bioreactor because:
AIt prevents cell division entirely
BIt sterilises the construct
CIt removes the scaffold
DPhysical stimuli direct cell differentiation and matrix organisation
Answer is hidden